The BEIR V preferred relative risk models and standard life-table techniques are used to project lifetime fatal cancer risk factors for average members of the Canadian
population. Uncertainties associated with projections are evaluated for: (1) sampling variation (statistical error), (2) extrapolation of risks to low doses and low dose rates, (3)
projection of excess lifetime cancer risks beyond the current periods of human observation in epidemiological studies, (4) the transfer of site-specific excess risk coefficients between
populations with differing baseline cancer rates, and (5) the effect of differences in the age and sex distributions among occupations in the Canadian "radiation" workforce. Results are
used to assess the applicability of the fatal cancer risk estimates recommended in ICRP publication 60 to the Canadian population.
It was found that sampling variation, extrapolating to low doses and dose rates, projecting excess risks beyond current periods of observation, and the uncertainty in how to
transfer site-specific excess risks between populations all cause substantial variations in lifetime cancer risk projections. Site-specific cancer risk projections may be
expected to vary by factors of 2 to 5, depending on the source of uncertainty.
Site-specific differences were found in the fatal cancer risk factors projected for "average" male and female workers among different occupations in the Canadian workforce.
Site-specific worker averages differed by as much as a factor 3. Female average risk factors for digestive cancers were substantially higher than male workers, while male average
risk factors tended to be higher for leukemia and respiratory cancer. Overall however, the majority of worker risk factors were within 2.5% of the site-specific projections for the
workforce as a whole.
The ICRP-60 nominal fatal cancer risk estimates, tissue weighting factors, and lifetime risk projections for prolonged radiation exposure were all in good agreement with
equivalent values derived in this report for the Canadian population. In view of the uncertainties, the results suggest the ICRP estimated cancer risks are as good as any presently available and supports the use of the ICRP recommended values for the planning and regulation of radiation protection in Canada. / Thesis / Master of Science (MS)
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/23782 |
| Date | 12 1900 |
| Creators | Rasmussen, Len R. |
| Contributors | Pomroy, C, Webber, C.E., Health and Radiation Physics |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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