Yes / Phencyclidine (PCP) produces cognitive deficits of relevance to schizophrenia in animal models. The
aim was to investigate the efficacy of the D1-like receptor agonist, SKF-38393, to improve PCPinduced
deficits in the novel object recognition (NOR) and operant reversal learning (RL) tasks. Rats
received either sub-chronic PCP (2 mg/kg) or vehicle for 7 days, followed by a 7-day washout. Rats
were either tested in NOR or the RL tasks. In NOR, vehicle rats successfully discriminated between
novel and familiar objects, an effect abolished in PCP-treated rats. SKF-38393 (6 mg/kg) significantly
ameliorated the PCP-induced deficit (Pb0.01) an effect significantly antagonised by SCH-23390
(0.05 mg/kg), a D1-like receptor antagonist (Pb0.01). In the RL task sub-chronic PCP significantly
reduced performance in the reversal phase (Pb0.001); SKF-38393 (6.0 mg/kg) improved this PCPinduced
deficit, an effect antagonised by SCH-23390 (Pb0.05). These results suggest a role for D1-like
receptors in improvement of cognitive function in paradigms of relevance to schizophrenia.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/8483 |
| Date | 27 January 2009 |
| Creators | McLean, Samantha, Idris, Nagi F., Woolley, M.L., Neill, Joanna C. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2009 Elsevier B.V. Reproduced in accordance with the publisher's self-archiving policy. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/, CC-BY-NC-ND |
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