When an organism is dehydrated, neurons in the Organum vasculosum lamina terminalis (OVL T) sense this variation in plasma osmolality (OSM) and excite magnocellular neurosecretory cells (MNCs) in the supraoptic nucleus (SON) via glutamatergic synapses. The resulting action potential firing of MNCs will result in the secretion of vasopressin (VP) into the blood, which will promote water reabsorption from the kidney. The relationship between plasma VP and OSM (know as the VP-OSM ratio) is known to change in sensitivity during the course of a day. / Lorsqu'un organisme est déshydraté, les neurones dans l'Organum vasculosum lamina terminalis (OVL T) détectent le changement dans l'osmolalité du plasma (OSM) et excitent les cellules magnocellulaires neurosécrétoires (MNCs) dans le noyau supraoptique (SON) avec des synapses glutamatergique. La décharge des potentiels d'action qui survient dans les MNCs génère la sécrétion de vasopressine (VP) dans le sang, qui permettra la réabsorption d'eau au niveau du rein. Le rapport entre la VP et OSM (connu comme étant le rapport VP/OSM) subit des changements de sensibilité durant une journée.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.104065 |
| Date | January 2009 |
| Creators | Trudel, Eric, 1978- |
| Contributors | Bourque, Charles W. (Supervisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | French |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Neurology and Neurosurgery) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 003591657, Theses scanned by McGill Library. |
Page generated in 0.0219 seconds