Corn oil (CO) and Sterculic foetida oil (SFO) fed rats were
injected with [9, 10-methylene-¹⁴C]sterculic acid. Less than 1%
of the label was expired as carbon dioxide. The majority of the
label was excreted in the urine as short-chain dicarboxylic acids with
an intact cyclopropane ring. The major metabolites for both CO and
SFO fed rats were cis-3, 4-methylene adipic acid and cis-3, 4-
methylene suberic acid. Sterculic acid must undergo β- and
[Greek w]-oxidation to form these urinary metabolites, α-oxidation played
a minor role in the formation of cis- and trans-3, 4-methylene pimelic
acid. Rats on the SFO diet could metabolize sterculic acid faster
than fats on the CO diet. However, both CO and SFO fed rats
produced the same urinary metabolites.
CO fed rats incorporated more label from sterculic acid into
protein and acid soluble liver fractions than SFO fed rats. Less than
0.01% of the label from either group was found in liver lipid sterol
or glycerol fractions.
There was a tendency for SFO fed rats to metabolize n-[1-¹⁴C]
octadecane faster than CO fed rats. This suggests that sterculic
acid may induce [Greek w]-hydroxylation of n-octadecane. / Graduation date: 1977
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/26185 |
| Date | 02 June 1976 |
| Creators | Eisele, Thomas Anthony |
| Contributors | Nixon, Joseph E. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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