Analgesias induced by an interaction between restraint and morphine, an interaction between exposure to a novel environment and morphine, and by restraint alone were all shown to be dependent upon an increase in brain tryptophan uptake. Further investigation of the analgesia induced by an interaction between retraint and morphine revealed that the increase in brain tryptophan uptake was induced by sympathetic activity and that the nucleus raphe magnus, the nucleus raphe dorsalis, and the periaqueductal gray were critical to the analgesia. Examination of the endogenous opiod activity critical to analgesia induced by restraint alone revealed that the opioid activity was in the central nervous system and independent of tryptophan uptake. The findings reported in this thesis may be delineating a general mechanism for analgesia that involves stress, serotonin, and opioids.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.72061 |
| Date | January 1985 |
| Creators | Kelly, Sandra, 1958- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 000230238, proquestno: AAINL24064, Theses scanned by UMI/ProQuest. |
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