Sandra Pavlíčková Physiological effects mediated by the brain angiotensin receptors Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Department of Biological and Medical Science Supervisor: Doc.MUDr. Josef Herink, DrSc. Renin-angiotensin system (RAS) is one of the oldest and the most important hormonal systems. "Classic" angiotensin system regulates the blood pressure and homeostasis of water and electrolytes. The main bioactive peptide of this system is angiotensin II (Ang II), which, according to recent research, does not affect only one organ. Installation of the so-called "tissue" RAS, which in many cases complements "systemic" Ang II system, changes the view on RAS. It was established, that RAS components are located on other non- typical places, which cannot be incorporated to the known endocrinal function of this system. Especially, discovery of angiotensin components and receptors in brain led to formation of new hypothesis and functional concepts about local effects of RAS, based on local synthesis of Ang II and angiotensin IV (Ang IV). Current studies found that physiological effects of the central angiotensin receptors can play an important role in neuroprotection and brain perfusion, can affect stress and behavioral disorders and influence...
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:330097 |
| Date | January 2013 |
| Creators | Pavlíčková, Sandra |
| Contributors | Herink, Josef, Kovařík, Miroslav |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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