by Lai-pang Law. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 148-182). / ABSTRACT / LIST OF ILLUSTRATIONS / LIST OF TABLES / ACKNOWLEDGEMENTS / ABBREVIATIONS / Chapter CHAPTER I --- INTRODUCTION --- p.1 / Chapter CHAPTER II --- LITERATURE REVIEW --- p.4 / Chapter 2.1 --- The uterus and its changes in the normal menstrual cycle / Chapter 2.2 --- Anatomy and physiology of normal myometrium / Chapter 2.3 --- Clinical features and management of uterine leiomyoma / Chapter 2.4 --- Pathology of human uterine leiomyoma / Chapter 2.5 --- The relationship between growth fractions and ER in breast carcinoma / Chapter 2.6 --- Steroid receptors and epidermal growth factor receptor / Chapter 2.6.1 --- Steroid receptors / Chapter 2.6.2 --- Epidermal growth factor receptor / Chapter 2.7 --- "Structures of oestrogen receptor, progesterone receptor, Ki-67 and epidermal growth factor receptor" / Chapter 2.7.1 --- The structure of oestrogen receptor / Chapter 2.7.2 --- The structure of progesterone receptor / Chapter 2.7.3 --- The structure of Ki-67 / Chapter 2.7.4 --- The structure of epidermal growth factor receptor / Chapter 2.8 --- "Antibodies to steroid receptors, monoclonal Ki-67 and epidermal growth factor receptor" / Chapter 2.8.1 --- Steroid receptors / Chapter 2.8.2 --- Monoclonal Ki-67 / Chapter 2.8.3 --- Epidermal growth factor receptor / Chapter 2.9 --- "Functions of steroid receptors, Ki-67 and epidermal growth factor receptor" / Chapter 2.9.1 --- The functions of steroid receptors / Chapter 2.9.2 --- The functions of Ki-67 / Chapter 2.9.3 --- The functions of epidermal growth factor receptor / Chapter 2.10 --- Cell cycle / Chapter 2.11 --- Immunohistochemistry / Chapter 2.11.1 --- Introduction / Chapter 2.11.2 --- Methodology of immunostaining / Chapter 2.11.3 --- Avidin-biotin-peroxidase complex technique / Chapter 2.11.4 --- Chromogens / Chapter 2.11.5 --- Enhancement methods / Chapter 2.11.6 --- Fixation for immunohistochemistry / Chapter CHAPTER III --- MATERIALS AND METHODS --- p.63 / Chapter 3.1 --- Reagents and chemicals / Chapter 3.1.1 --- Primary monoclonal antibodies / Chapter 3.1.2 --- Secondary antibodies / Chapter 3.1.3 --- Avidin-biotin complex / Chapter 3.1.4 --- DAB solution / Chapter 3.1.5 --- Buffers / Chapter 3.1.6 --- Miscellaneous / Chapter 3.2 --- Patients and specimens / Chapter 3.2.1 --- Specimen collection / Chapter 3.2.2 --- Preparation of specimens / Chapter 3.3 --- Immunohistochemical staining / Chapter 3.3.1 --- Slide preparation / Chapter 3.3.2 --- Antigen retrieval / Chapter 3.3.3 --- Procedures of immunohistochemical staining / Chapter 3.3.4 --- Interpretation of immunostaining / Chapter CHAPTER IV --- RESULTS --- p.80 / Chapter 4.1 --- Clinical information / Chapter 4.2 --- Oestrogen receptor / Chapter 4.3 --- Progesterone receptor / Chapter 4.4 --- Epidermal growth factor receptor / Chapter 4.5 --- Ki-67 / Chapter CHAPTER V --- DISCUSSION --- p.120 / Chapter 5.1 --- Methods and interpretation of the results / Chapter 5.1.1 --- The advantages of the immunohistochemical staining technique / Chapter 5.1.2 --- Interpretation and reporting of immunohistochemical results / Chapter 5.1.3 --- Interpretation of the results by semi- quantitative assessment and statistical analysis / Chapter 5.2 --- The status of steroid receptors in uterine leiomyoma / Chapter 5.2.1 --- ER status in uterine leiomyoma and normal myometrium / Chapter 5.2.2 --- PR status in uterine leiomyoma and normal myometrium / Chapter 5.3 --- EGF-R status in uterine leiomyoma / Chapter 5.4 --- Ki-67 status in uterine leiomyoma and normal myometrium / Chapter 5.5 --- "The relationship between steroid receptors, Ki-67, EGF-R and uterine leiomyoma growth" / Chapter 5.6 --- Biological indices in the assessment of tumor / Chapter 5.7 --- Microwave technology in immunohistology for surgical pathology / Chapter CHAPTER VI --- CONCLUSIONS --- p.144 / REFERENCES --- p.148
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_322012 |
| Date | January 1997 |
| Contributors | Law, Lai-pang., Chinese University of Hong Kong Graduate School. Division of Surgical Sciences. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English |
| Detected Language | English |
| Type | Text, bibliography |
| Format | print, 182 leaves : ill. (some col.) ; 30 cm. |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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