Parkinson’s disease (PD) is accompanied by a significant amount of beta β-band (11Hz-30Hz) neuronal and local field potential (LFP) oscillatory activity in the subthalamic nucleus (STN). The aim of this study was to measure the spatial extent of β coherent activity in the STN and coherence between STN-SNr in PD patients OFF levodopa by systematically varying the vertical distance between two microelectrodes. We found significant β-LFP coherence across the dorsoventral extent of STN. Spatially extended beta LFP was positively correlated with the mUPDRS scores of the PD patients in the OFF state. Additionally, a significant coherence was found between β-LFPs in dorsal STN and dorsal SNr. These data suggest that the whole STN may be entrained within the β band in PD patients OFF meds. The finding of coherence between STN and SNr suggests that β oscillations synchronize both the input and output nuclei of the basal ganglia.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33309 |
| Date | 20 November 2012 |
| Creators | Alavi, Mahan |
| Contributors | Hutchison, William D. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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