Objective: The purpose of this investigation is to examine the association of genetic variations in 4 single nucleotide polymorphisms (SNPs) of the AKT1 gene and 3 SNPs of the AMPKá2 gene with percent change in lean muscle mass, arm mass-adjusted strength, and leg mass-adjusted strength following a resistance exercise training (RET) program while controlling for the effects of age, gender, and RET history. These genes are part of the mTOR signaling pathway, which has been shown to be an important mediator of protein synthesis in adult animals. Design: Participants were young men and women (age 18-31) from the Molecular Epidemiology of Resistance Exercise Training (MERET) study who completed 10 weeks of RET. Participants trained 3 days per week at 75% of one repetition maximum, performing 3 sets (6-10 repetitions) of 13 resistance exercises. Results: There were no significant associations between the individual AKT1 and AMPKá2 SNPs examined in this investigation to percent changes in lean muscle mass, arm mass-adjusted strength, or leg mass-adjusted strength following RET. However, significant interactions between various SNPS of the AKT1 and AMPKá2 genes and measures of muscle mass and strength were observed. Conclusion: The results of this investigation suggest that future research involving the mTOR signaling pathway and its association to variations in the individual response of skeletal muscle response to standardized RET is warranted.
| Identifer | oai:union.ndltd.org:PITT/oai:PITTETD:etd-08022008-153935 |
| Date | 29 September 2008 |
| Creators | Newman, Mark A |
| Contributors | Robert J. Robertson PhD, Fredric L. Goss PhD, Steven E. Riechman, Bret H. Goodpaster PhD |
| Publisher | University of Pittsburgh |
| Source Sets | University of Pittsburgh |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.pitt.edu/ETD/available/etd-08022008-153935/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to University of Pittsburgh or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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