The principal work in this thesis describes the investigation of the impact that alterations to ocular aberrations following refractive surgery have on the accommodative mechanism. A series of prospective studies were conducted with healthy adults (n=36) that had chosen to undergo refractive surgery at Manchester Royal Eye Hospital. A variety of monocular accommodative functions were assessed prior to surgery and then at one and three months following surgery on the same cohort of patients. Accommodative functions included amplitude of accommodation, accommodative facility (at 6m and 0.4m) including positive and negative response times, and accommodative stimulus-response functions. Dynamic accommodation responses were examined in a subgroup (n=10) at three months following refractive surgery and compared to an age-matched emmetropic control group (n=10) to evaluate differences in latency, amplitude, time constant and peak velocity of accommodation and disaccommodation. During the studies, ocular aberrations were concurrently measured to determine whether alterations to aberrations could help explain any observed changes in accommodative functions. Evaluation of visual, refractive and questionnaire outcome measures indicated that the patient cohort underwent successful surgery. Following surgery, significant alterations to a number of accommodative functions were discovered. Mean subjective ocular amplitude of accommodation increased by approximately 0.50D (p<0.05), mean stimulus-response function gradient decreased by approximately 10% (p<0.05) and distance facility rate increased by approximately 2-3 cycles/minute (p<0.05). Significant correlation was found between the change in accommodative stimulus-response function gradient, and the change in spherical aberration following surgery (p<0.05). Significant differences were also found in the parameters of accommodative dynamics, although some of these factors may be explained by refractive error differences between the refractive surgery patients (pre-operative myopes) and the emmetropic control group. The results suggest that alterations to aberrations following refractive surgery may be capable of influencing elements of the accommodation response. Additional studies were conducted to investigate the changes in aberrations during accommodation (n=31 subjects), and explore the contribution of the tear film (n=19 subjects) to higher order aberrations in eyes that have undergone refractive surgery. The results suggested that the rate of change in aberrations during accommodation is not affected by refractive surgery, but that the pattern of aberrations induced by post-blink tear film changes may differ in patients that have undergone refractive surgery. A further study is presented which investigated the form of the accommodative stimulus-response function to grating target of different spatial frequencies in groups of myopic (n=10) and emmetropic (n=10) participants recruited from among the staff and students at The University of Manchester. Both refractive groups appeared to show similar accommodative behavior, however the dominant feature of the data in both groups was between subject variation.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:686705 |
| Date | January 2011 |
| Creators | Taylor, John |
| Contributors | O'Donnell, Clare ; Radhakrishnan, Hema |
| Publisher | University of Manchester |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | https://www.research.manchester.ac.uk/portal/en/theses/accommodation-refractive-surgery-and-ocular-aberrations(e457724c-b681-4957-ae7d-6ccdb2f0765d).html |
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