The lens is a crystallin tissue of the anterior part of the eye that focuses light onto the
retina. Aged-related cataract, which is the result of loss of lens transparency, is the most
common cause of blindness in the world. Being constantly exposed to UV-light, lens is
significantly affected by its UVA spectrum. UV-light exposure has been shown to result
in apoptosis of lens cells which can lead to cataract formation. This suggests the need for
molecular mechanisms to remove apoptotic debris from the lens. In the set of
experiments it was proven that integrin αvβ5-mediated pathway is involved in
phagocytosis of apoptotic cell debris in the ocular lens, thus contributing to its
homeostasis. Additionally, it was shown that exposure to UV-light plays role in cataract
formation by influencing integrin αvβ5-mediated phagocytosis function. / Includes bibliography. / Thesis (M.S.)--Florida Atlantic University, 2016. / FAU Electronic Theses and Dissertations Collection
| Identifer | oai:union.ndltd.org:fau.edu/oai:fau.digital.flvc.org:fau_33511 |
| Contributors | Bakina, Olga (author), Kantorow, Marc (Thesis advisor), Florida Atlantic University (Degree grantor), Charles E. Schmidt College of Medicine, Department of Biomedical Science |
| Publisher | Florida Atlantic University |
| Source Sets | Florida Atlantic University |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation, Text |
| Format | 42 p., application/pdf |
| Rights | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder., http://rightsstatements.org/vocab/InC/1.0/ |
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