本論文敘述了 III-B類輪烷樹狀物的人工合成及其表徵。透過重覆(1) 經改良的 銅(I) 催化炔烴 -疊氮偶極環加成反應 (2) 生成醯胺鍵以及最後 (3) 格拉澤 -希偶聯反應合成第一代 (G1) 及第二初代 (G2 ’)IIIB類輪烷樹狀物。 銨鹽啞及冠醚被採用來組合成分支結構的偽輪烷。 III B類輪烷樹狀物被核磁共振波譜法及電噴霧離子化法－質譜所表徵。這項研究為 III-B類輪烷樹狀物合成研究提供不可或缺的雛型 。這項研究為超分子及高化學家開拓新的領域，給予他們研究III-B類輪烷樹狀物的特性及其生醫學和電子應用機會。 / In this thesis, the syntheses and characterizations of a series of Type III-B Rotaxane Dendrimers are described. First generation (G1) and prototypical second generation (G2’) Type IIIB Rotaxane Dendrimer, which incorporate rotaxane features as the branching units, were synthesized by employing consecutive (1) modified Copper-Catalyzed Alkyne-Azide Cycloaddition (CuAAC), (2) amide formation through stopper molecule and pseudorotaxanes, and (3) GlaserHay’s acetylene homo-coupling reaction. Pseudorotaxanes with ammonium thread and crown ether macrocycle were employed. The Type III-B Rotaxane Dendrimers were characterized by nuclear magnetic resonance (NMR) spectroscopy, electrospray ionisationmass spectrometry (ESI-MS). This study provides an indispensable prototype to the synthesis of novel Type III-B Rotaxane Dendrimer. It opened up great opportunity for supramolecular and polymer chemists to further explore the properties and biomedical and electronic application of the novel dendrimers. / Detailed summary in vernacular field only. / Ho, Kwok Wai. / "October 2012." / Thesis (M.Phil.)--Chinese University of Hong Kong, 2013. / Includes bibliographical references (leaves 49-51). / Abstracts also in Chinese. / Contents --- p.i / Acknowledgments --- p.ii / Abstract --- p.iii / Abbreviations and Acronyms --- p.v / Synthetic Studies Towards Type III-B Rotaxane Dendrimer / Chapter Chapter 1 --- Introduction / Chapter 1.1 --- Classification of Rotaxane Dendrimers --- p.2 / Chapter 1.2 --- Type II-B Rotaxane Dendrimer --- p.5 / Chapter 1.3 --- Application of Copper Catalyzed Alkyne Azide Cycloaddtion(CuAAC) in Rotaxane Synthesis --- p.8 / Chapter 1.4 --- Potential Application of Type III-B Rotaxane Dendrimer --- p.12 / Chapter 1.5 --- Aim of Project --- p.14 / Chapter Chapter 2 --- Synthetic Studies Towards of Type III-B Rotaxane Dendrimer / Chapter 2.1 --- Design and Synthesis of Type III-B Rotaxane Dendrimer --- p.15 / Chapter 2.2 --- Characterization of G1 and G2’ Type III-B Rotaxane Dendron/Dendrimer --- p.27 / Chapter 2.2.1 --- ¹H NMR Spectroscopy --- p.27 / Chapter 2.2.2 --- ¹³C NMR Spectroscopy --- p.32 / Chapter 2.2.3 --- Mass Spectrometry --- p.32 / Chapter 2.3 --- Conclusion --- p.38 / Chapter Chapter 3 --- Experimental Procedures / Chapter 3.1 --- General Information --- p.39 / Chapter 3.2 --- Experimental Procedures --- p.40 / References / Appendix / List of Spectra --- p.A1
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_328665 |
| Date | January 2013 |
| Contributors | Ho, Kwok Wai., Chinese University of Hong Kong Graduate School. Division of Chemistry. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | electronic resource, electronic resource, remote, 1 online resource (v, 51, A15 leaves) : ill. (some col.) |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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