Ischemic heart disease (IHD) is a leading cause of global mortality. Emerging evidence suggests a potential role of the gut microbiome in IHD development. The present study explored the association between alpha diversity, representing microbial richness and evenness, and IHD, as well as the relationship between specific gut microbial species and IHD risk. The study uses a longitudinal design with data from the two cohorts within the Swedish Infrastructure for Medical Population-based Life-course and Environmental Research (SIMPLER). Survival analysis is employed to calculate the hazard rate for all associations. Because of thecompositionality of the gut microbiome species-level data a centered log-ratio (CLR) transformation is applied before the main analysis. We find no associations between alpha diversity and risk of IHD in the age and sex-adjusted model as well as in the main model adjusted for age, sex, smoking, education, physical activity, hypertension, high cholesterol, and intakes of fish, red and processed meat, fermented dairy, fruit and vegetables and alcohol. Five species are found to be statistically significantly associated with IHD in the main model before correction for multiple testing, which is statistically non-significant after the correction.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-531936 |
| Date | January 2024 |
| Creators | Gabrielsson, David |
| Publisher | Uppsala universitet, Statistiska institutionen |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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