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Studium interakce záporně nabitých vezikulárních systémů s polykationty / Study of interaction of negatively charged vesicular systems with polycations

This diploma thesis deals with the preparation and characterization of negatively charged catanionic vesicular systems and their combination with selected polycations. The catanionic vesicular system was prepared by mixing of two oppositely charged surfactants SDS and CTAB. The negative charge as well as the stability of the vesicular system was provided by the incorporation of phosphatidic acid. Polycations, DEAE and TMC, have been selected for use in a pharmaceutical applications. Characterization of the prepared systems was performed by measuring DLS and ELS. The results indicate that we were able to prepare stable negatively charged vesicles that were eligible to non-covalently interact with selected polycations.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:414178
Date January 2020
CreatorsRepová, Romana
ContributorsKlučáková, Martina, Mravec, Filip
PublisherVysoké učení technické v Brně. Fakulta chemická
Source SetsCzech ETDs
LanguageSlovak
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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