Methylmercury (MeHg) is an environmental contaminant mainly present in fish and seafood. The long-term consumption of these fish and seafoods could pose a health risk to pregnant women and their children. Animal studies were conducted to assess the effects of MeHg exposure on reproduction and offspring development as well as the potential benefits of nutrient supplementation. Adult female rats were treated by gavage with MeHg at dose levels of 0.5, 1.0 or 2.0 mg/kg/day for 4 weeks prior to mating and throughout pregnancy, and then were allowed to deliver. In a second study, adult female rats were treated with MeHg at 1.25 mg/kg/day for the same duration, and they were fed diets containing an extra 1 ppm selenium (Se), or 225 IU/kg vitamin E, or both of these two nutrients, 4 weeks prior to MeHg dosing, and then throughout McHg treatment. (Abstract shortened by UMI.)
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.32762 |
| Date | January 2002 |
| Creators | Beyrouty, Peter. |
| Contributors | Chan, M. H. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Natural Resource Sciences.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001875993, proquestno: MQ78834, Theses scanned by UMI/ProQuest. |
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