The SARS-CoV-2 pandemic has been a worldwide chronic, stress-inducing
natural catastrophe associated with increased emotional challenging. Patients with
Post-traumatic stress disorder (PTSD), self-injury behavior, and obesity are predisposed
to aggravation of their symptoms at this time, requiring new therapeutic approaches to
balance their disrupted neuro-hormonal stress axis. Here we present our observations
of an off-label treatment with lamotrigine in an adolescent girl with PTSD, self-injury
behavior, and obesity. Lamotrigine was an efficacious pharmaceutical intervention that
helped the patient deal with chronic stress and associated anxiety. The results are
discussed based on our previous basic research outcomes in animals and humans that
focused on the glutamate-cortisol circuits within the limbic brain.
| Identifer | oai:union.ndltd.org:DRESDEN/oai:qucosa:de:qucosa:84485 |
| Date | 31 March 2023 |
| Creators | Pham, Thuylinh L., Chrousos, George P., Merkenschlager, Andreas, Petrowski, Katja, Ullmann, Enrico |
| Publisher | Frontiers Research Foundation |
| Source Sets | Hochschulschriftenserver (HSSS) der SLUB Dresden |
| Language | English |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, doc-type:article, info:eu-repo/semantics/article, doc-type:Text |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 1664-0640 |
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