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Predikce škodlivosti aminokyselinových mutací s využitím metody MAPP / Predicting the Effect of Amino Acid Substitutions on Protein Function Using MAPP Method

This thesis discusses the issue of predicting the effect of amino acid substitutions on protein function using MAPP method. This method requires the multiple sequence alignment and phylogenetic tree constructed by third-party tools. Main goal of this thesis is to find the combination of suitable tools and their parameters to generate the inputs of MAPP method on the basis of analysis on one massively mutated protein. Then, the MAPP method is tested with chosen combination of parameters and tools on two large independent datasets and consequently is compared with the other tools focused on prediction of the effect of mutations. Apart from this the web interface for the MAPP method was created. This interface simplifies the use of the method since the user need not to install any tools or set any parameters.

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:236151
Date January 2014
CreatorsPelikán, Ondřej
ContributorsVogel, Ivan, Bendl, Jaroslav
PublisherVysoké učení technické v Brně. Fakulta informačních technologií
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/masterThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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