Objective: Study the clinical, genetic and serological factors associated with new onset ileal inflammation in ulcerative colitis (UC) patients who have undergone ileal pouch-anal anastomosis (IPAA).
Methods: Retrospective assessment of UC patients registered in the MSH surgical database, questionnaire, chart review and serological and genetic analysis of blood sample.
Results: There was a positive association between gASCA antibodies, anti-L, smoking status and axial arthritis/ankylosing spondylits with a Crohn’s Disease (CD)-like phenotype post-op in UC/IPAA patients. Associations between alleles of selected genes including ECM1, PTPN2, and CD14 and post-operative phenotype were identified.
Conclusions: gASCA is typically associated with CD rather than UC which raises the possibility that gASCA positivity may delineate a subset of UC patients at risk for developing a CD-like phenotype after IPAA. The identification of genotype/phenotype associations in UC/IPAA will help to find those at risk for poor post-operative outcome. Prospective studies are needed to confirm these findings.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/18951 |
| Date | 16 February 2010 |
| Creators | Verbeeten, Diane |
| Contributors | Silverberg, Mark |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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