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Effect of Operant Behavior on the Metabolism of 5-Hydroxytryptamine

The role of operant behavior in the metabolism of brain 5-hydroxytryptamine (5-HT) turnover was investigated. Two and one-half hours following the administration of 150 mg/kg of para-chlorophenylalanine (PCPA), a specific inhibitor of tryptophan hydroxylase, levels of 5-HT were compared in sedentary and performing rats. Whole brain levels of serotonin were reduced in both responding and sedentary animals; however, differences between these groups were not statistically significant. The drug induced decrease in 5-HT levels was accompanied by a significant decrease in session responding. The degree of suppressed responding could be correlated with the level of 5-HT following PCPA, suggesting that the metabolism of serotonin is in part modulated by the rate of responding as maintained by the operant schedule.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc503958
Date08 1900
CreatorsShepard, Paul
ContributorsRedden, David R., Emmett-Oglesby, M. W. (Michael W.), Schafer, Rollie
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatv, 87 leaves: ill., Text
RightsPublic, Shepard, Paul, Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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