The potential use of polymeric, functionalized nanoparticles (NPs) as drug delivery vectors was explored. Covalent conjugation of albumin to the surface of NPs via maleimide chemistry proved problematic. However, microwave assisted synthesis of NPs was not only time efficient, but enabled the exploration of size control by changing the following parameters: temperature, microwave power, reaction time, initiator concentration, and percentage of monomer used. About 1.5 g of fluorescently-labeled, carboxylic acid-functionalized NPs (100 nm diameter) were synthesized for a total cost of less than $1. Future work will address further functionalization of the NPs for the coupling of albumin (or other targeted proteins), and tests for in vivo biodistribution.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc30466 |
| Date | 08 1900 |
| Creators | Hinojosa, Barbara R. |
| Contributors | Petros, Robby A., Borden, Weston T. |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | vii, 69 p. : ill., Text |
| Rights | Public, Copyright, Hinojosa, Barbara R., Copyright is held by the author, unless otherwise noted. All rights reserved. |
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