High fibre diets are associated with reduced risk of type 2 diabetes mellitus (T2DM). This may be due to short-chain-fatty-acids (SCFA) influencing insulin resistance and secretion via changes in free-fatty-acids (FFA) and specific gut hormones. We aimed to determine the postprandial effects of inulin, a fermentable, soluble fibre in healthy subjects.
Twelve fasted subjects were studied for 6 hours after either 80g high fructose corn syrup (HFCS), 56g HFCS plus 24g inulin, or 56g HFCS drinks using a randomized, cross-over design.
SCFA were higher after inulin beginning at 4 hours. FFA were lower 4 hours after inulin than 56gHFCS. GLP-1 was higher 30 minutes after inulin than 56 and 80HFCS, while ghrelin was lower from 4-6 hours after inulin.
The results support the hypothesis that inulin and SCFA generated from colonic fermentation of dietary fibre may improve insulin resistance and secretion via modulation of FFA and specific gut hormones.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18956 |
| Date | 16 February 2010 |
| Creators | Tarini, Joshua |
| Contributors | Wolever, Thomas M. S. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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