This thesis investigated the role of CBF assessment in the management of stroke in children with
sickle cell disease (SCD). It is divided into two parts. In the first part, a systematic review of CBF
assessment using different imaging modalities in SCD children was designed. The prevalence of
CBF abnormalities was found to be equal to or higher than those of structural MRI and
transcranial Doppler (TCD) in SCD children who have not experienced stroke. Studies reviewed
suggested CBF assessment in SCD could aid in addressing brain abnormalities at the tissue level.
In the second part, the arterial spin labeling (ASL) technique was used to depict CBF
abnormalities in SCD children. ASL demonstrated perfusion abnormalities that seem to remain
invisible in TCD measurements; CBF interhemispheric asymmetries were associated with
clinically silent infarctions with no corresponding flow velocity interhemispheric asymmetries
assessed with TCD.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/33369 |
| Date | 21 November 2012 |
| Creators | Behpour, Amir Mahmood |
| Contributors | Kassner, Andrea |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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