No / A series of structurally related citric acid-ciprofloxacin conjugates was synthesised to investigate the influence of the linker between citric acid and ciprofloxacin on antibacterial activities. Minimum inhibitory concentrations (MICs) were determined against a panel of reference strains and clinical isolates of bacteria associated with infection in humans and correlated with the DNA gyrase inhibitory activity. The observed trend was rationalised by computational modelling.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/10512 |
| Date | January 2014 |
| Creators | Milner, S.J., Snelling, Anna M., Kerr, Kevin G., Abd-El-Aziz, A., Thomas, G.H., Hubbard, R.E., Routledge, A., Duhme-Klair, A-K. |
| Source Sets | Bradford Scholars |
| Detected Language | English |
| Type | Article, No full-text available in the repository |
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