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Single-cell Sequencing Studies of Somatic Mutation in the Human Brain

A major unanswered question in neuroscience is whether there exists genomic variability between individual neurons of the brain, contributing to functional diversity or to an unexplained burden of neurologic disease. To address this question, we developed methods to amplify genomes of single neurons from human brains, achieving >80% genome coverage of single-cells and allowing study of a wide-range of somatic mutation types.

Identiferoai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11151539
Date January 2013
CreatorsEvrony, Gilad David
ContributorsWalsh, Christopher A
PublisherHarvard University
Source SetsHarvard University
Languageen_US
Detected LanguageEnglish
TypeThesis or Dissertation
Rightsclosed access

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