The chemical constituents of organic extracts of two Formosan soft corals Sinularia leptoclados and Sinularia nanolobata were studied. Investigation on S. leptoclados has led to the isolation of eight norditerpenes (1-8), including four new compounds, scabrolide A (1), leptolide A (2), leptolide B (3), leptolide C (4) and four know compounds (5-8), (11, 12)-epileptolide (5), ineleganolide (6), (1R*,5R*,8R*,10S*,11S*)¡V11¡Vhydroxyl¡V1¡Visopropenyl¡V8¡Vmethyl¡V3,6¡Vdioxo¡V5,8¡Vepoxycyclotetradec¡V12¡Vene¡V10,12¡Vcarbolactone (7) and (1R*,5R*,8R*,10S*,11R*)¡V11¡Vhydroxyl¡V1¡Visopropenyl¡V8¡Vmethyl¡V3,6¡Vdioxo¡V5,8¡Vepoxycyclotetradec¡V12¡Vene¡V10,12¡Vcarbolactone (8). Also, investigation on the chemical constituents of S. nanolobata has led to the isolation of two new compounds (9-10), nanolobatallin A (9) and nanolobatallin B (10). The structures of the new metabolites were determined on the basis of spectroscopic analyses, including MS, IR, 1D and 2D NMR.
The cytotoxicities of the isolates against the NUGC, HONE-1, KB and Hepa59T/VGH cancer cell lines were studies. Compounds 7, 8 and 10 showed moderate cytotoxicity against KB and Hepa59T/VGH cancer cell lines. Compound 9 exhibited moderate cytotoxicity against Hepa59T/VGH cancer cells.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0821102-180820 |
| Date | 21 August 2002 |
| Creators | Shiue, Ru-Ting |
| Contributors | Jung-Nan Lin, Yung-Chang Wu, Jr-Hung Sheu |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0821102-180820 |
| Rights | unrestricted, Copyright information available at source archive |
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