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Změny endokrinní funkce a zánětlivého profilu tukové tkáně a periferních monocytů u pacientů s obezitou: vliv fyzické aktivity a bariatrické chirurgie / The changes in endocrine function and inflammatory profile of adipose tissue and peripheral monocytes of patients with obesity: the influence of physical activity and bariatric surgery

(EN) Research in the field of obesity, diabetes mellitus and their complications in recent years is increasingly focused on pathophysiological mechanisms of their onset and potential prevention and treatment. The aim of the present work was to evaluate the effects of two different interventions - sleeve gastrectomy and physical activity - on anthropometric, biochemical, hormonal parameters and mRNA expression of proinflammatory factors in subcutaneous adipose tissue along with mRNA expression in peripheral blood monocytes in patients who underwent sleeve gastrectomy. A total of 15 obese women with hypertension were included into the physical activity study. These patients underwent a 3-month training program, which included 30 minutes of aerobic exercise three times a week. 13 obese women were included into sleeve gastrectomy study and were followed-up for 2 years after surgery. Our results indicate that in both studies obese groups had at baseline significantly increased mRNA expression of proinflammatory cytokines, adipokines, chemokines and chemokine receptors relative to control groups. Both interventions decreased body weight and low-grade inflammation. Physical activity had no significant effect on blood pressure, lipid profile and mRNA expression of the components of the renin-...

Identiferoai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:370954
Date January 2017
CreatorsTrachta, Pavel
ContributorsHaluzík, Martin, Maruna, Pavel, Štechová, Kateřina
Source SetsCzech ETDs
LanguageCzech
Detected LanguageEnglish
Typeinfo:eu-repo/semantics/doctoralThesis
Rightsinfo:eu-repo/semantics/restrictedAccess

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