<p dir="ltr">A study on the impact of the position of the attachment of the photolabile, backbone amide linker, 4-formyl-3-hydroxy-5-nitrobenzoic acid, on the synthesis of a model cyclic pentapeptide was conducted. The peptide was synthesized on a solid support and cleaved photolytically. The crude product was analyzed for the effect of changing position by LC/MS, 1HNMR, and yield. The target peptide could not be identified convincingly by LC/MS or NMR. It was observed that attachment of the backbone amide linker to the N alpha of tyrosine provided the highest crude product yield.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/24729585 |
| Date | 05 December 2023 |
| Creators | Khalil Castillo-Aponte (17551896) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/An_Investigation_into_the_Effect_of_Backbone_Amide_Linker_Position_on_the_Solid_Phase_Peptide_Synthesis_of_a_Cyclic_Pentapeptide/24729585 |
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