We aim to develop an implantable, optical neural imaging device by fabricating lasers and photodiodes onto a gallium arsenide substrate. Some studies suggest that lasers exhibit higher noise than light emitting diodes (LEDs) due to coherence effects – my studies aim to quantify this noise and to guide device development. To this end, I developed a model of a fluorescent imaging device which agreed with experiment. Noise analysis performed in phantom showed that laser sources exhibit temporal and spatial noise up to 10x higher than LED sources, and in vivo noise analysis also demonstrated this trend. I studied a neural injury model called cortical spreading depression in vitro in mouse brain slices and in vivo in the rat brain using laser and LED sources. Signal magnitudes in vitro are on the order of 10% and in vivo results are inconclusive. Future work will aim to reduce coherence related noise.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OTU.1807/18918 |
| Date | 15 February 2010 |
| Creators | Munro, Elizabeth Alice |
| Contributors | Levi, Ofer |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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