In non-inferiority trials, the goal is to show how an experimental treatment is statistically and clinically not inferior to the active control. The three-arm clinical trial usually recommended for non-inferiority trials by the FDA. The three-arm trial consists of a placebo, reference, and an experimental treatment. The three-arm trial shows the superiority of the reference over the placebo and comparison of the reference to an experimental treatment. In this paper, I will assess a non-inferiority trial with Bayesian methods. By employing Bayesian analysis, the parameters are random and assign vague prior distributions. I will compare the models involving different prior distributions to assess the best fit model.
| Identifer | oai:union.ndltd.org:GEORGIA/oai:digitalarchive.gsu.edu:math_theses-1026 |
| Date | 03 May 2007 |
| Creators | Britton, Marcus Chenier |
| Publisher | Digital Archive @ GSU |
| Source Sets | Georgia State University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Mathematics Theses |
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