Febrile seizures are epileptic seizures, arising in connection with febrile conditions in children of prechool age. In adults with epilepsy is often present a history of febrile status epilepticus, seizure whose duration is longer than 20 minutes. To study the role of febrile status epilepticus (FSE) in the development of epilepsy and neuronal damage, it is necessary to have a relevant animal models. This work is focused on the morphological analysis of the new created model of febrile status epilepticus, using a combination of short-term hyperthermia and chemical induced status epilepticus at 10 days old rats. In adulthood, the animals were examined by video/EEG monitoring, and then morphometric analysis. The aim of this study was to determine the importance of short-term hyperthermia during SE for neuropathological changes using stereological measurements of hippocampal volume.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:306699 |
| Date | January 2012 |
| Creators | Chott, Robert |
| Contributors | Kubová, Hana, Otáhal, Jakub |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
Page generated in 0.0021 seconds