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Myokardrevaskularisation bei hochgradig eingeschränkter linksventrikulärer Funktion

Faktoren, die die funktionelle Erholung von hibernating myocardium nach aortokoronarem Venen Bypass (ACVB) beeinflussen, werden gegenwärtig untersucht. Von 3/2000 bis 3/2003 untersuchten wir prospektiv 41 Patienten mit einer linksventrikulären Ejektionsfraktion (LVEF) / Objectives: Factors that influence functional recovery of hibernating myocardium after coronary artery bypass grafting are at present under investigation. Methods: From 3/2000 to 3/2003 we prospectively analyzed 41 patients with ejection fraction (EF) 15% during DE in group I preoperatively; the increase was < 15% in group II. MRI hyperenhancement was measured with a mean of 16,7±11,6% of the left ventricle in group I compared to a mean of 27,4±14,4% in group II (p 19µm) in group I than in group II (< 17µm). Gene expression of pro-apoptotic genes such as BAK and BAX was lowered (0.5±0.1/0.8±0.1) compared to "normal" myocardium (1.0±0.1) (p

Identiferoai:union.ndltd.org:HUMBOLT/oai:edoc.hu-berlin.de:18452/14561
Date11 March 2004
CreatorsHausmann, Harald
ContributorsSilber, R. E., Körfer, R.
PublisherHumboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité
Source SetsHumboldt University of Berlin
LanguageGerman
Detected LanguageEnglish
TypedoctoralThesis, doc-type:doctoralThesis
Formatapplication/pdf, application/octet-stream, application/octet-stream

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