在許多實驗研究中，實驗數據經常由有序觀測數據組成，這樣的例子很容易在醫學、臨床研究、社會學或心理學的研究中找到。一般有兩種方法可以用來分析有序分類數據。第一種方法是基於Wilcoxon-Mann-Whitney 統計量的非參數方法，第二種方法是把響應變量看成是某個連續潛變量模型的一種表現的潛變量模型。在本論文中，我們主要研究基於潛變量模型對具有一維或二維有序分類響應變量的處理的比較問題，同時解決具有一維有序分類數據的多重比較過程的功效及樣本量的確定問題。 / 潛變量模型已經被應用于對具有一維有序分類觀測數據的含有對照組的多重比較中。這種方法可以很好地應用于臨床研究中對含有對照組的不同治療方法的效用比較問題。在本論文的第一部份中，我們致力於把這種思想推廣到成對多重比較，成對多重比較是臨床研究中另一個很重要的課題。我們通過隨機模擬來對不同的方法在控制整體第一類錯誤和功效的優勢進行評估。在本論文的第二部份，我們主要研究具有二維有序分類響應變量的多重比較過程。在這些過程中，我們把二維有序分類數據看成是某個潛二維變量的一種表現。非參數方法也經常被應用於做兩個處理的比較問題。然而在本文中，我們對非參數方法的劣勢進行了說明。處理具有二維有序分類響應變量的含有對照組的多重比較問題是本論文的研究重點。基於潛變量模型的方法，我們給出了含有對照組的多重比較的若干檢驗過程，包括單步檢驗過程和逐步檢驗過程。在論文的第三部份，我們對具有一維有序分類數據的含有對照組的多重比較過程的功效和樣本量的確定問題進行了討論。基於Lu, Poon and Cheung (2012) 建議的多重比較過程，我們得到了滿足一定功效的樣本量的確定方法，并通過實例進行了說明。 / In many scientific studies, research data are frequently composed of ordered categorical observations. Numerous examples could easily be found in areas including medical and clinical studies, sociology and psychology. There are two popular approaches in analyzing ordered categorical data. One is to employ the non-parametric method based on the Wilcoxon-Mann-Whitney statistics. The other is to use the latent variable model that conceptualizes the responses as manifestations of some underlying continuous variables. In this project, we focus on the comparisons of different populations with either univariate or bivariate ordered categorical observations using a latent variable model. The study of power and sample size requirement for multiple testing with univariate ordered categorical data are also provided in this thesis. / For univariate ordered categorical observations, the latent variable model has been used to compare treatments with a control. The developed methods are useful for applications in clinical studies where one would like to compare the efficacy of different treatments with a given control/placebo. In this thesis, we seek to extend this idea to develop the useful procedures for pairwise multiple comparisons which are often important objectives of clinical trials. Extensive simulation studies regarding overall type I error rate and power are performed to evaluate the merits of different procedures. / The second part of this thesis is devoted to multiple comparison methods with bivariate ordered categorical responses under the assumption that the bivariate ordered categorical data are manifestations of an underlying bivariate normal distribution. To compare two population mean vectors, nonparametric procedures are also frequently being used, but as demonstrated in this thesis, these methods are inferior to testing procedures based on the latent variable model. Hence, by the adoption of the latent variable model, we develop procedures that can be used to conduct multiple comparisons with a control for bivariate categorical responses. Different multiple comparison mechanisms including single-step and stepwise procedures are explored. Numerical examples for illustrative purposes are also given. / For the last part of this thesis, we discuss power and sample size determination for multiple comparisons with control for univariate ordered categorical data. Based on the multiple testing procedures proposed by Lu, Poon and Cheung (2012), we derive the procedure to compute the required sample size that guarantee a pre-specified power level. Numerical examples are also given. / For the last part of this thesis, we discuss power and sample size determination for multiple comparisons with control for univariate ordered categorical data. Based on the multiple testing procedures proposed by Lu, Poon and Cheung (2012), we derive the procedure to compute the required sample size that guarantee a pre-specified power level. Numerical examples are also given. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Lin, Yueqiong. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2012. / Includes bibliographical references (leaves 92-100). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstract also in Chinese. / Abstract --- p.i / Acknowledgement --- p.iv / Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Overview --- p.1 / Chapter 1.2 --- Outline of the thesis --- p.4 / Chapter 2 --- Pairwise Comparisons with Ordered Categorical Responses --- p.6 / Chapter 2.1 --- Introduction --- p.6 / Chapter 2.2 --- Proportional odds model --- p.8 / Chapter 2.3 --- Latent variable model --- p.11 / Chapter 2.4 --- Pairwise comparisons --- p.15 / Chapter 2.4.1 --- Single-step procedure and the computation of critical values . --- p.15 / Chapter 2.4.2 --- Approximation of critical values --- p.16 / Chapter 2.4.3 --- A single-step conservative testing procedure: the Bonferroni procedure --- p.18 / Chapter 2.4.4 --- A step-wise testing procedure: Hochberg's step-up procedure . --- p.19 / Chapter 2.5 --- Simulation: power comparison --- p.20 / Chapter 2.6 --- Examples --- p.24 / Chapter 2.7 --- Conclusion --- p.28 / Chapter 3 --- Multiple comparison procedures for a latent variable model with bivariate ordered categorical responses --- p.29 / Chapter 3.1 --- Introduction --- p.29 / Chapter 3.2 --- Latent bivariate normal model --- p.31 / Chapter 3.2.1 --- The model --- p.31 / Chapter 3.2.2 --- Model specification --- p.33 / Chapter 3.2.3 --- Test Statistics --- p.35 / Chapter 3.2.4 --- Statistical inference --- p.35 / Chapter 3.3 --- Nonparametric test --- p.37 / Chapter 3.3.1 --- Test statistic --- p.39 / Chapter 3.3.2 --- A Comparison between the latent variable model procedure and nonparametric tests --- p.42 / Chapter 3.4 --- Multiple comparisons of several treatments with a control based on the latent variable model --- p.47 / Chapter 3.5 --- Simulation --- p.51 / Chapter 3.6 --- Examples --- p.56 / Chapter 3.7 --- Conclusion --- p.59 / Chapter 4 --- Sample size determination for multiple comparisons with ordered univariate categorical data --- p.62 / Chapter 4.1 --- Introduction --- p.62 / Chapter 4.2 --- Multiple comparisons of treatments a control with ordered categorical responses --- p.64 / Chapter 4.3 --- Power function --- p.67 / Chapter 4.4 --- Sample size determination and tables --- p.75 / Chapter 4.5 --- Examples --- p.85 / Chapter 4.6 --- Conclusion --- p.88 / Chapter 5 --- Further Research --- p.90 / Bibliography --- p.92 / Appendix / Chapter A --- Procedures to obtain the MLE of parameter θ₀ --- p.101 / Chapter B --- Nonparametric test --- p.105 / Chapter C --- Procedures to obtain the critical value for Dunnett's single-step procedure --- p.109 / Chapter D --- Procedures to obtain the critical value for Dunnett's single-step procedure with balanced homogeneous groups --- p.112
| Identifer | oai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_328296 |
| Date | January 2012 |
| Contributors | Lin, Yueqiong., Chinese University of Hong Kong Graduate School. Division of Statistics. |
| Source Sets | The Chinese University of Hong Kong |
| Language | English, Chinese |
| Detected Language | English |
| Type | Text, bibliography |
| Format | electronic resource, electronic resource, remote, 1 online resource (x, 113 leaves) : ill. (some col.) |
| Rights | Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
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