2,5-diketopiperazines peculiar heterocyclic system found in several natural products constitutes a rich source of new biologically active compounds. The wide spectrum of their biological properties points to various therapeutic possibilities. Introduction of structural rigidity, resulting in diketopiperazine derivatives containing a pyridine ring that can form an intramolecular hydrogen bond,and shows an interesting activity. In our research, we hope to probe further the importance of structural rigidity with regards to biological activity. We hope to replace the hydrogen bonding between the pyridine ring and amide nitrogen with a covalent link. This will further restrict the rotation and isomerization of the Z-double bond.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0731108-120315 |
| Date | 31 July 2008 |
| Creators | Pan, Hsiu-Tz |
| Contributors | Meng-Yang Chang, Chi-Wi Ong, Ming-Jung Wu |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0731108-120315 |
| Rights | not_available, Copyright information available at source archive |
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