Release of substance P-like immunoreactivity (SP-LI) was measured from isolated perfused guinea-pig hearts. Capsaicin (1 μM) caused a substantial increase in the amount of SP-LI detected in perfusate compared to values during exposure to vehicle or drug-free buffer. Tachyphylaxis developed to the effect of capsaicin on release of SP-LI and to its effect on physiological parameters. These data show SP-LI can be released from cardiac sensory nerves and suggest SP could mediate a portion of the response of the isolated heart to capsaicin.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-12959 |
| Date | 23 September 1987 |
| Creators | Hoover, Donald B. |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Source | ETSU Faculty Works |
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