The distribution of substance P (SP) binding sites in guinea-pig airway was examined by in vitro autoradiography with tritium and iodine-labeled SP. Specific SP binding sites were most abundant in tracheobronchial smooth muscle but were also detected in the mucosa/submucosa. Binding within the mucosa/submucosa was especially high in the region of glands. Binding of iodine-labeled SP to cartilage was negligible. Tritium-labeled SP bound non-specifically to airway cartilage. These observations are consistent with the proposed effects of SP-containing afferent nerves on airway resistance and vascular permeability. The localization of specific SP binding sites suggests that SP may also affect exocrine glands in the respiratory tract.
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-14054 |
| Date | 01 January 1987 |
| Creators | Hoover, Donald B., Hancock, John C. |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Source | ETSU Faculty Works |
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