No / Background: Slowness of movement, known as bradykinesia, is the core clinical sign of Parkinson's and fundamental to its diagnosis. Clinicians commonly assess bradykinesia by making a visual judgement of the patient tapping finger and thumb together repetitively. However, inter-rater agreement of expert assessments has been shown to be only moderate, at best.
Aim: We propose a low-cost, contactless system using smartphone videos to automatically determine the presence of bradykinesia.
Methods: We collected 70 videos of finger-tap assessments in a clinical setting (40 Parkinson's hands, 30 control hands). Two clinical experts in Parkinson's, blinded to the diagnosis, evaluated the videos to give a grade of bradykinesia severity between 0 and 4 using the Unified Pakinson's Disease Rating Scale (UPDRS). We developed a computer vision approach that identifies regions related to hand motion and extracts clinically-relevant features. Dimensionality reduction was undertaken using principal component analysis before input to classification models (Naïve Bayes, Logistic Regression, Support Vector Machine) to predict no/slight bradykinesia (UPDRS = 0–1) or mild/moderate/severe bradykinesia (UPDRS = 2–4), and presence or absence of Parkinson's diagnosis.
Results: A Support Vector Machine with radial basis function kernels predicted presence of mild/moderate/severe bradykinesia with an estimated test accuracy of 0.8. A Naïve Bayes model predicted the presence of Parkinson's disease with estimated test accuracy 0.67.
Conclusion: The method described here presents an approach for predicting bradykinesia from videos of finger-tapping tests. The method is robust to lighting conditions and camera positioning. On a set of pilot data, accuracy of bradykinesia prediction is comparable to that recorded by blinded human experts.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18414 |
| Date | 21 March 2021 |
| Creators | Williams, S., Relton, S.D., Fang, H., Alty, J., Qahwaji, Rami S.R., Graham, C.D., Wong, D.C. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, No full-text in the repository |
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