The physiological significance of noradrenergic sympathohabenular ingrowth following medial septal lesions was investigated. Following septal lesions, sympathetic fibers originating in the superior cervical ganglia are known to sprout into the medial habenular nuclei, and into the hippocampal formation. Previous work involving sympathohippocampal ingrowth showed that firing rates in septal animals with no ingrowth showed that firing rates in septal animals with no ingrowth were higher than rates of septal animals with ingrowth and controls. Those results suggested that sympathetic ingrowth in the hippocampus had some functional capability in a modulatory manner. The primary aim of the present study was to determine if the peripheral sympathetic ingrowth into the medial habenular nuclei following a septal lesion is functionally significant. The results showed that firing rates of neurons of the medial habenulae in animals receiving septal lesions were significantly higher than rates of control animals and septal lesioned + ganglionectomized animals.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc798080 |
| Date | 08 1900 |
| Creators | Howard, A. Jean (Ava Jean) |
| Contributors | Pirtle, Robert M., Jacobson, Myron, Cook, Paul F., Gracy, Robert W., Jacobson, Elaine |
| Publisher | North Texas State University |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | vi, 87 leaves : ill., Text |
| Rights | Public, Howard, A. Jean (Ava Jean), Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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