Indiana University-Purdue University Indianapolis (IUPUI) / Taxane-induced musculoskeletal pain (TIMP) is musculoskeletal pain that
includes myalgia (i.e., diffuse muscle pain, usually accompanied by malaise) and/or
arthralgia (i.e., joint pain) that occurs following treatment with taxane-based
chemotherapy. TIMP is a symptom that is clinically reported as negatively affecting most
cancer survivors receiving taxane-based chemotherapy; however, TIMP is not
comprehensively understood. The purpose of this dissertation was to conduct a cross
sectional, descriptive, correlational pilot study to describe TIMP in women with ovarian
cancer who were being or had been treated with paclitaxel-containing regimens. Specific
aims were to: (1) describe the TIMP symptom experience (intensity, distress, duration,
location, quality, temporal pattern, aggravating and alleviating factors, and pain
management); (2) describe the associations between TIMP (intensity, distress) and co
occurring symptoms (pain [general], peripheral neuropathy, impaired sleep, fatigue,
emotional distress, and/or hot flashes); and (3) identify associations between TIMP
(intensity, distress) and patient-reported outcomes (interference with daily activities,
physical functioning, and health-related quality of life). Primary data collection was
performed on a convenience sample of 15 women with ovarian cancer. Participants
were recruited from an outpatient cancer clinic, local cancer support communities, and a
national cancer survivors’ research registry. Descriptive statistics and Spearman’s
correlations were used.
Findings showed TIMP is moderate to severe in intensity on average, constant,
affecting a large area of the body, and aggravated by everyday walking. Greater TIMP
intensity or distress was associated with greater intensity and interference of most co-occurring symptoms and was associated with greater interference with daily activities,
worse physical functioning, and worse health-related quality of life. Nurses are
encouraged to comprehensively assess TIMP using structured, validated tools for pain
to better intervene on aggravating and alleviating factors and pain management
regimens. Prospective, longitudinal studies with larger sample sizes are needed to
further understand TIMP and its impact on cancer survivors.
| Identifer | oai:union.ndltd.org:IUPUI/oai:scholarworks.iupui.edu:1805/13760 |
| Date | 18 April 2017 |
| Creators | Davis, Lorie Lynn |
| Contributors | Carpenter, Janet S., Otte, Julie L., Kroenke, Kurt, He, Chuyan, Smith, Sophia |
| Source Sets | Indiana University-Purdue University Indianapolis |
| Language | en_US |
| Detected Language | English |
| Type | Dissertation |
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