Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.
| Identifer | oai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11151534 |
| Date | 07 June 2014 |
| Creators | Mardinly, Alan Robert |
| Contributors | Greenberg, Michael Eldon |
| Publisher | Harvard University |
| Source Sets | Harvard University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Rights | open |
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