The tablet is the preferred route of delivery for pharmaceutical products to its relative ease of manufacture and high patient compliance. However, complex tablet formulations can present a number of process challenges, necessitating careful design of both the formulation and the process. This thesis sets out to investigate some of the issues involved with the lubrication of roller compaction formulations in order to gain a greater understanding of the role of lubrications. A systematic study on the effect of magnesium stearate during feeding and compaction in a horizontally fed roller compactor has been conducted. The feasibility of a novel external lubrication was investigated as an engineering solution to prevent adhesion to roll surfaces in the absence of magnesium stearate from the formulation. Alternative formulation strategies and lubricants have been investigated to find suitable materials that provide similar lubricating properties to magnesium stearate whilst exhibiting less detrimental effects on the tablet strength and tablet dissolution. The feasibility of using surrogate APIs as an aid to facilitate process and formulation design of investigational drug products was tested using a statistical analysis of the response data obtained from an experimental design.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:607290 |
| Date | January 2014 |
| Creators | Dawes, Jason |
| Publisher | University of Birmingham |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://etheses.bham.ac.uk//id/eprint/5160/ |
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