A spectroscopic probe with multiple detecting fibers was used for quantifying absorption and scattering in liquid optical phantoms. The phantoms were mixtures of Intralipid and red and blue food dyes. Intensity calibration for the detecting fibers was undertaken using either a microsphere suspension (absolute calibration) or a uniform detector illumination (relative calibration between detectors). Two different scattering phase functions were used in an inverse Monte Carlo algorithm. Data were evaluated for residual spectra (systematic deviations and magnitude) and accuracy in estimation of scattering and absorption. Spectral fitting was improved by allowing for a 10% intensity relaxation in the optimization algorithm. For a multi-detector setup, non-systematic residual spectrum was only found using the more complex Gegenbauer-kernel phase function. However, the choice of phase function did not influence the accuracy in the estimation of absorption and scattering. Similar estimation accuracy as in the multi-detector setup was also obtained using either two relative calibrated detectors or one absolute calibrated detector at a fiber separation of 0.46 mm. / <p>Funding Agencies|VINNOVA||Perimed AB|2008-00149|ResearchGrow program|2011-03074|European Union||Linkoping University through the Center for Excellence NIMED-CBDP (Center for Biomedical Data Processing)||</p>
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:liu-78815 |
| Date | January 2012 |
| Creators | Karlsson, Hanna, Fredriksson, Ingemar, Larsson, Marcus, Strömberg, Tomas |
| Publisher | Linköpings universitet, Biomedicinsk instrumentteknik, Linköpings universitet, Tekniska högskolan, Linköpings universitet, Biomedicinsk instrumentteknik, Linköpings universitet, Tekniska högskolan, Linköpings universitet, Biomedicinsk instrumentteknik, Linköpings universitet, Tekniska högskolan, Linköpings universitet, Biomedicinsk instrumentteknik, Linköpings universitet, Tekniska högskolan, Optical Society of America |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Article in journal, info:eu-repo/semantics/article, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | Optics Express, 1094-4087, 2012, 20:11, s. 12233-12246 |
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