<p>Perfluoroalkyl substances are synthetic organic chemicals of
environmental concern because they have been associated with adverse effects in
both human epidemiological studies and standard laboratory animals. In the
environment, PFAS occur as mixtures, especially in areas with a history of PFAS
application, such as aqueous film forming foam (AFFF) sites. Among the PFAS, perfluorooctanesulfonic
acid (PFOS) and perfluorohexanesulfonic acid (PFHxS) are the most common, and
occur at the highest concentrations. Thus, amphibian populations at or near
AFFF sites are at risk of exposure to known bioaccumulative and persistent
chemicals, likely compromising the physiology and body condition of the
animals. Here, we exposed northern leopard frogs to environmentally relevant
concentrations of 0.5 and 1 ppb PFOS and PFHxS, alone or as a mixture comprised
of 0.5 ppb PFOS and 0.5 ppb PFHxS. Univariate analyses showed that in the
larval stages, tadpoles exposed to PFAS had significantly reduced scaled mass
indexes (SMI’s) relative to the control, and only the organisms exposed to PFHxS
0.5 ppb were significantly larger. Sex did not significantly influence toxicity
in the later stages (GS 42 & 46), indicating no sex-related effects.
Altered body condition (i.e., fat stores) in the larval stages indicate
potential effects to energy balance. There is a need to assess fitness-related
effects as amphibians’ transition into the terrestrial environment, and include
endpoints such as: reproductive, developmental, immunological, mating, feeding,
competition, and survival. Early developmental effects in the larval stages
also suggests that earlier developmental endpoints may be of interest. Establishing ecological risk assessments for
PFAS are necessary, as they are toxic, persistent, and bioaccumulative.</p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/14596893 |
| Date | 14 May 2021 |
| Creators | Edgar Ramiro Perez (10802253) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/AN_ENVIRONMENTALLY_RELEVANT_BINARY_MIXTURE_OF_PERFLUOROOCTANESULFONIC_ACID_AND_PERFLUOROHEXANESULFONIC_ACID_RESULTS_IN_ANTAGONISM_AND_REDUCED_BODY_CONDITION_IN_NORTHERN_LEOPARD_FROGS/14596893 |
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