The hypothesis of this study was that dietary n-3 fatty acids protect against phenytoin (P) teratogenicity by inhibiting embryonic prostaglandin H synthase bioactivation of P and/or by delaying embryonic development. Female caesarian-derived (CD-1) mice were fed a safflower (SAFF)- or a cod liver/linseed oil (CLO/LO)-based diet for three weeks prior to impregnation and throughout pregnancy. The CLO/LO diet, compared to the SAFF diet, reduced malformations and fetal growth retardation due to P. Open eye defect was the only anomaly induced by P in CLO/LO fetuses while P produced cleft palates only in SAFF fetuses. Since the period of maximal susceptibility to open eye defect occurs before palatal closure, this result suggests that the CLO/LO diet delayed development relative to the SAFF diet. In Exp 2, dietary n-6/n-3 fatty acid ratios were reflected in maternal hepatic phospholipids. Lipid peroxidation (LPO) was induced in maternal hepatic tissues by the SAFF diet while LPO was induced by P only in CLO/LO embryos.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.56661 |
| Date | January 1992 |
| Creators | High, Kim |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (School of Dietetics and Human Nutrition.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001313698, proquestno: AAIMM80436, Theses scanned by UMI/ProQuest. |
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