Recent studies in the field of dyslexia have used magnetic resonance spectroscopy (MRS) to explore neurochemical manifestations of neurobiological differences in the brains of dyslexic adults compared to controls. This study examines the potential relationship between functional magnetic resonance imaging (fMRI) BOLD (blood oxygen level demand) activation scores in response to cognitive tasks and MRS-measured levels of a metabolite and a neurotransmitter, N-acetylaspartate (NAA) and gamma-aminobutyric acid (GABA) respectively, in the occipital region of brains of seven-year old children. Preliminary results from this multi-arm, longitudinal study indicate a significant positive correlation between fMRI BOLD signal elicited in response to picture-cues in the occipital region of interest bilaterally, and both GABA (R2=0.477 p=0.05, 2-tailed) and NAA (R2=0.587 p=0.01, 2-tailed) levels. The results suggest that the functional neuroanatomical circuitry involved in a cognitive task also has neurochemical indicators.
| Identifer | oai:union.ndltd.org:YALE_med/oai:ymtdl.med.yale.edu:etd-08092007-144458 |
| Date | 14 February 2008 |
| Creators | Ibrahim, Hassana Aisha |
| Contributors | Robert Fulbright |
| Publisher | Yale University |
| Source Sets | Yale Medical student MD Thesis |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://ymtdl.med.yale.edu/theses/available/etd-08092007-144458/ |
| Rights | unrestricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Yale School of Medicine or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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