Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2012. / Crystal engineering is the synthesis of new crystalline materials with specific chemical and
physical properties which allows the comprehensive understanding of the non covalent
interactions that occur between molecules in the crystalline state. This has lead to extensive
work being done in terms of host design. The study of non-covalent interactions formed by -
these materials is crucial to understanding many biological processes.
This study focuses on the inclusion compounds of 1, 4-bis (diphenylhydroxymethyl) benzene
H, a host compound engineered by EWeber, that conforms to Weber's rules for host design
as it is bulky, rigid, and has hydroxyl moieties that act as hydrogen-bonding donors. A
Cambridge Structural Database (CSDversion 5.33) search has revealed that no research has
been conducted on this host compound. Characterization of the compounds were
conducted using thermogravimetric analysis (TGA), differential scanning calorimetry (DSC),
hot stage microscopy (HS), gas chromatography (GC), powder X-ray diffraction(PXRD) and
single X -ray diffraction. Host: guest ratios determined from TG analysis were correlated
with structural analysis results.
We have successfully prepared inclusion compounds with N, N- dimethylformamide(DMF)
N, N- dimethylacetamide (DMA), N-methylformamide (NMF) and N-methylacetamide
(NMA), 2-picoline, 3-picoline, 4-picoline, pyridine and morpholine. Following which a series
of competition experiments were conducted to establish the selectivity profile of the host
by dissolving the host in an excess of two guests pairs, between DMF: DMA, DMF: NMF,
DMF: NMA, DMA: NMF, DMA: NMA and NMF: NMA. The results of the competition
experiment showed that the host had high selectivity for DMF and the selectivity profile
follows a trend as follows DMF>NMA>NMF>DMA. The results for the competition
experiments between the picolines, pyridine and morpholine were inconclusive.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:cput/oai:localhost:20.500.11838/2618 |
| Date | January 2012 |
| Creators | Silwana, Nothemba |
| Contributors | Jacobs, Ayesha |
| Publisher | Cape Peninsula University of Technology |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | http://creativecommons.org/licenses/by-nc-sa/3.0/za/ |
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