M. Tech. Pharmaceutical Sciences. / Xenogeneic collagen has previously been reported to be a poor delivery system for bone morphogenetic proteins, because of its immunogenic effects in the host. In the laboratory the researcher uses, the problems associated with the xenogeneic bone matrix has been overcome by chemical swelling employing acetic acid followed by pepsin digestion to reduce telopeptides. This has improved host biocompatibility. The central focus of the current study was to improve the performance of the previously developed delivery system by employing a combination of BMP-2 and TGF-ß1 in a rat heterotopic assay.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:tut/oai:encore.tut.ac.za:d1000452 |
| Date | January 2011 |
| Creators | Sibiya, Sibusiso Jeffrey. |
| Contributors | Duneas, N., Olivier, E. I. |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Text |
| Format |
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