The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3

Description

The effects of agitation rate, buffer molarity,and mesh size on the dissolution rate of verapamil hydrochloride from sustained release matrix tablets were studied using USP Apparatus 3. Eudragit® and Carbopol® were used as rate-retarding polymers in tablets prepared by wet granulation.The study was conducted to determine whether the drugs exhibit similar release characteristics when tested under the same dissolution conditions. It was found that the dissolution rate of verapamil hydrochloride was affected by the variables assessed in these studies.

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1. http://eprints.ru.ac.za/735/1/The_effects_of_buffer_molarity%2C_agitation_rate_and_mesh_size_on_verapamil_release_from_MR_mini-tablets_using_USP_Apparatus_III.pdf
2. Khamanga, S.M.M. and Walker, R.B. (2007) The effects of buffer molarity, agitation rate and mesh size on verapamil release from modified release mini-tablets using USP Apparatus 3. Dissolution Technologies, 14 (2). pp. 19-23. ISSN 1521-298X

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Identifer	oai:union.ndltd.org:Rhodes/oai:eprints.ru.ac.za:735
Date	05 1900
Creators	Khamanga, S.M.M., Walker, R.B.
Source Sets	Rhodes University SA
Detected Language	English
Type	Article, PeerReviewed
Format	application/pdf
Relation	http://www.dissolutiontech.com/DTresour/200705Articles/DT200705_A02.pdf, http://eprints.ru.ac.za/735/