INTRODUCTION: HIV/AIDS is a global health problem, with Sub-Saharan Africa the most
affected. “Neuro-AIDS” refers to the extensive neuropathological manifestations of the
disease. Neuroimaging of the HIV-infected individual plays a fundamental role in their
work-up. Limited resources, however, drive the development of imaging protocols based
on clinical signs. ‘Confusion’ may or may not represent a significant presenting sign and
needs to be investigated, as it is the basis of referral of a significant number of patients
for CT scanning.
AIM: To determine the frequency of positive findings of head CT in HIV-infected adults
presenting with confusion with/without associated neurology, and correlate them with
the degree of immunosuppression, presence of CSF abnormality and their ARV therapy
status.
METHOD: CT brain scans of adult patients, who were HIV-positive and presented with
confusion in Johannesburg, Gauteng, were retrospectively reviewed. The neurological
status, CD4 counts, LP results and their ARV therapy status were documented.
RESULTS: 30% of our HIV-infected patients presented with confusion. There were 156
patients who were included. CT scans were abnormal in 81%. We found that ‘associated
neurology’ was a weak predictor for abnormal CT, making it a poor screening tool. A
positive LP was predictive of infection (p=0.04 for focal infection, p=0.03 for infected
surface collection) and infarction (p<0.01) on CT. CD4 count, LP results and ARV therapy
were found to be abnormal in the majority of patients.
CONCLUSIONS: CT was abnormal in the majority of HIV-infected patients presenting with
confusion. Neurology was an unreliable clinical indicator. A positive LP was a good
predictor for CT evidence of infection and infarction. The clinical parameters such as CD4
counts, LP results and ARV therapy, were abnormal in the majority of patients. If any of
these parameters are abnormal in a patient with a normal CT, we believe this should
motivate for further imaging with MRI.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:wits/oai:wiredspace.wits.ac.za:10539/14411 |
| Date | 28 March 2014 |
| Creators | Sewchuran, Tanusha |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | application/pdf |
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