Effects of Toxaphene®, a polychlorinated terpene insecticide, were studied by a multidisciplinary approach on two cockroach species, Leucophaea maderae (F.) and Periplaneta americana (L.). Toxaphene was found to be slightly toxic to L. maderae and moderately toxic to P. americana. Uptake of ³⁶C1-toxaphene in tissues of L. maderae was studied from 2 to 120 hours. Greater accumulation of ³⁶C1-toxaphene on a ug/gm basis was found associated with the abdominal ventral nerve cord (VNC) of L. maderae than with haemolymph, fat body, and alimentary canal. ³⁶C1-toxaphene uptake was noted in L. maderae VNC in vitro at levels which were independent of incubation dose concentration. Substantial amounts of ³⁶C1-toxaphene remained associated with VNC after rinsing. Radiolabeled material found in haemolymph of asymptomatic L. maderae appeared to be qualitatively different from toxaphene standards and also that found in symptomatic insect haemolymph based on gas chromatography. Concentration levels responsible for in vivo toxicity appeared to correlate with electrophysiological symptomology in VNC of P. americana. Intense forms of activity were observed in isolated nerve preparations and in VNC removed rom symptomatic insects treated with 1/10⁵ and 1/10¹ M toxaphene. Latent periods between introductioon of toxaphene and onset of intense activity appeared to vary as a function of concentration.
| Identifer | oai:union.ndltd.org:arizona.edu/oai:arizona.openrepository.com:10150/348046 |
| Date | January 1976 |
| Creators | Dary, Curtis Carl |
| Publisher | The University of Arizona. |
| Source Sets | University of Arizona |
| Language | en_US |
| Detected Language | English |
| Type | text, Thesis-Reproduction (electronic) |
| Rights | Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. |
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