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Trombocitų funkcijos ir krešėjimo sistemos aktyvumo pokyčiai gydant širdies ritmo sutrikimus radijo dažnine abliacija / Changes in the platelet function and the coagulation system activity in the treatment of heart arrhythmias by radiofrequency catheter ablation

Radiofrequency catheter ablation (RFA) is a rapidly developing, minimally invasive method of treatment for heart arrhythmias. Its employment is however limited due to complications, including thromboembolic ones. The basic of seven objectives of this dissertation were to: 1. by using different agonists of aggregation, to evaluate alteration of platelet aggregation in the venous blood and platelet-rich plasma, fibrinogen and D-dimer levels before RFA, immediately after, 24 hours and 72 hours after RFA under the influence of RFA in patients suffering from heart arrhythmia; 2. to establish the influence of the total RFA energy, structural heart disease, antithrombotic medicines know in the alteration of platelet aggregation induced by different agonists and in the alteration before RFA, immediately after and 24 hours after RFA. The obtained data show that changes in PA after RFA depended on whether PA proceeded in the venous blood or plasma and on the agonist used to induce aggregation. According to the results, PA is suppressed immediately after RFA and increases in 24 hours. The level of the applied total energy had an effect on changes in platelet aggregation after RFA. The dynamics of PA in patients with and without a structural heart disease were similar. The obtained pre-RFA values of PA were lower in blood and even lower in plasma in the group of patients who used aspirin, as compared to those who used low molecular mass heparin or no antithrombotic medicines. Despite the... [to full text]

Identiferoai:union.ndltd.org:LABT_ETD/oai:elaba.lt:LT-eLABa-0001:E.02~2006~D_20061219_114642-78022
Date19 December 2006
CreatorsKozlovaitė, Vilma
ContributorsPangonytė, Dalia, Naudžiūnas, Albinas, Grybauskas, Pranas, Dadonienė, Jolanta, Babarskienė, Rūta, Aniulienė, Albina, Braždžionytė, Julija, Didžiapetrienė, Janina, Kaunas University of Medicine
PublisherLithuanian Academic Libraries Network (LABT), Kaunas University of Medicine
Source SetsLithuanian ETD submission system
LanguageLithuanian
Detected LanguageEnglish
TypeDoctoral thesis
Formatapplication/pdf
Sourcehttp://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20061219_114642-78022
RightsUnrestricted

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